The 2021 Boston High School YRBS was administered during the fall of 2021 using rigorous protocols to ensure student confidentiality and data integrity. Students were randomly selected to participate using systematic probability sampling. The overall response rate was 73%. Data processing and analyses were performed by CDC. The results are weighted and considered representative of all Boston students in grades 9-12. Thank you to the BPS students who shared their personal experiences with us so we can have this valuable public health data.