| 1880 | Alice M. Mills, first graduating class of Girls' Latin School, first Alumnae President |
| 1909 | Marion Moreland, teacher and guidance counselor, Girls' Latin School |
| 1910 | Natalie W. Linderholm, Founder of Career Center for Social Service |
| 1914 | Alice C. Lacey, teacher and President of the Girls Latin School Alumnae Association |
| 1914 | Dr. Mary T. Rooney, First Dean of Seton Hall University Law School |
| 1915 | Julia Steere Clark, Teacher, Black Hills Teacher's College |
| 1920 | Pamela Robinson-Moore, Author of fiction and children's stories |
| 1921 | Marjorie Linfield Hansaker, Economist at Occidental College |
| 1921 | Zabelle Tahmizian, Teacher at GLS and translator of Armenia literature |
| 1926 | Norma Farber, Poet, author and concert singer |
| 1928 | Miriam Dickey, Member of the Children's Museum, and Mass. Audubon Society |
| 1928 | Sr. Anna Kelly, Assistant Dean of Regis College |
| 1930 | Bernice Rosenbaum, Founder, Social Workers for Peace and Nuclear Disarmament |
| 1931 | Barbara Polk Washburn, First woman to climb Mt. McKinley |
| 1932 | Eileen Donovan, Career Diplomat with service in the Philippines |
| 1933 | Harriet Schlesinger Annis, Director of Psychiatry at the Gaebler Children's Center |
| 1933 | Ruth Messer Anderson, Chief of Anesthesia at the Cushing VA Hospital |
| 1934 | Rita Kelley, Physician at Mass General Hospital |
| 1935 | Mary McGrory, Syndicated columnist for the Washington Star newspaper |
| 1937 | Lillian Gass Savage, Teacher at Sharon H.S. and founder of the Student Coalition Against Hatred and Racism |
| 1939 | Deborah Tepper Haimo, Professor of Mathematics at Washington University of Missouri |
| 1939 | Eleanor Creed L'Ecuyer, First woman officer to retire as Coast Guard Captain; Prof of GLS Alumnae Assoc. 1951-55 |
| 1940 | Eunice Alberts Nicholson, Soloist for Boston Symphony Orchestra |
| 1940 | Priscilla Laubenstein, Educator and designer of a Learning Aid Device for disadvantaged youth |
| 1941 | Nona Rohan Mahoney, Founder of Blue Hill Montessori School |
| 1941 | Margaret Hannigan, Dermatologist with Child & Family Health Services |
| 1942 | Martha Bergin Thomas, Engineer, Recipient of the Achievement Award from the Society of Women Engineers |
| 1943 | Maria-Pia Antonelli, Accomplished pianist & recipient of the Star of Italian Solidarity Award |
| 1947 | Aileen Cavanaugh, Boston University School of Management faculty and Physicists with the Dept. of Army |
| 1947 | Sr. Mary Hennesey, Served in student personnel at Loyola University |
| 1947 | Frances Fraher Minno, Lecturer in law at the University of Pittsburgh |
| 1948 | Jacquelyn Seevak Sanders, Author, lecturer and Director of the Sonia Shankman Orthogenic School at the University of Chicago |
| 1949 | Norma Meras Swenson, Author, lecturer and Director of the Boston Women's Health Book Collections |
| 1951 | Alice Koerner Wolf, Former Mayor of the City of Cambridge |
| 1952 | Sarah Ann Shaw, TV-reporter and former host of Say Brother |
| 1953 | Sylvia Simmons, Former Executive Director of the American Assistance Corp. |
| 1955 | Harriet Latham Robinson, Research Professor of UMASS Medical School |
| 1957 | Martina Souretis-Horner, Former President of Radcliffe College |
| 1961 | Diane White, Columnist for The Boston Globe |
| 1962 | Julie Glowacki, Ph.D., Professor of Orthopedic Surgery and Professor of Oral & Maxillofacial Surgery, Harvard School of Dental Medicine; Orthopedic Research, Brigham and Women's Hospital |
| 1968 | Jacqueline Adams, Reporter for CBS news |
See also the school's alumni web page and Boston Latin Academy Association.